Cayman Chemical Prostaglandin E1 isopropyl es
An amidine-incorporated degradable lipid (pKa 8.15) has been used in the generation of LNPs for the delivery of siRNA and mRNA in vitro or in vivo LNPs containing lipid 12T-O14 and encapsulating GFP-targeting siRNA reduce GFP levels in HepG2-GFP cells intramuscular delivery of LNPs containing lipid 12T-O14 and encapsulating SARS-CoV-2 spike-encoding mRNA increases anti-SARS-CoV-2 spike protein IgG titers in mice in a prime and boost immunization regimen LNPs containing lipid 12T-O14 accumulate in the liver but LNPs containing both lipid 12T-O14 and MC3 can be tuned to target the lungs or the spleen